Browsing by Author "Perrimon, N."
Now showing items 1-10 of 10
-
Article
Developmental biology: Our fly cousins' gut
Pitsouli, Chrysoula; Perrimon, N. (2008)What do we humans have in common with flies? Quite a lot, at least at the cellular and molecular levels. Our intestine, for instance, is similar to that of the fly, not only in function but also in its development and ...
-
Article
Embryonic multipotent progenitors remodel the Drosophila airways during metamorphosis
Pitsouli, Chrysoula; Perrimon, N. (2010)Adult structures in holometabolous insects such as Drosophila are generated by groups of imaginal cells dedicated to the formation of different organs. Imaginal cells are specified in the embryo and remain quiescent until ...
-
Article
Exploiting position effects and the gypsy retrovirus insulator to engineer precisely expressed transgenes
Markstein, M.; Pitsouli, Chrysoula; Villalta, C.; Celniker, S. E.; Perrimon, N. (2008)A major obstacle to creating precisely expressed transgenes lies in the epigenetic effects of the host chromatin that surrounds them. Here we present a strategy to overcome this problem, employing a Gal4-inducible luciferase ...
-
Article
The homeobox transcription factor cut coordinates patterning and growth during drosophila airway remodeling
Pitsouli, Chrysoula; Perrimon, N. (2013)A fundamental question in developmental biology is how tissue growth and patterning are coordinately regulated to generate complex organs with characteristic shapes and sizes. We showed that in the developing primordium ...
-
Article
Homeostasis in Infected Epithelia: Stem Cells Take the Lead
Pitsouli, Chrysoula; Apidianakis, Yiorgos; Perrimon, N. (2009)To maintain tissue homeostasis and avoid disease, epithelial cells damaged by pathogens need to be readily replenished, and this is mainly achieved by the activation of stem cells. In this Short Review, we discuss recent ...
-
Article
In vivo imaging of Drosophila melanogaster pupae with mesoscopic fluorescence tomography
Vinegoni, C.; Pitsouli, Chrysoula; Razansky, D.; Perrimon, N.; Ntziachristos, V. (2008)We report a technique for fluorescence tomography that operates beyond the penetration limits of tissue-sectioning fluorescence microscopy. The method uses multi-projection illumination and photon transport description in ...
-
Article
Mesoscopic fluorescence tomography for in-vivo imaging of developing Drosophila
Vinegoni, C.; Razansky, D.; Pitsouli, Chrysoula; Perrimon, N.; Ntziachristos, V.; Weissleder, R. (2009)Visualizing developing organ formation as well as progession and treatment of disease often heavily relies on the ability to optically interrogate molecular and functional changes in intact living organisms. Most existing ...
-
Article
Mesoscopic fluorescence tomography for in-vivo imaging of developing Drosophila.
Vinegoni, C.; Razansky, D.; Pitsouli, Chrysoula; Perrimon, N.; Ntziachristos, V.; Weissleder, R. (2009)Visualizing developing organ formation as well as progession and treatment of disease often heavily relies on the ability to optically interrogate molecular and functional changes in intact living organisms. Most existing ...
-
Article
Signaling mechanisms controlling cell fate and embryonic patterning
Perrimon, N.; Pitsouli, Chrysoula; Shilo, B. -Z (2012)During development, signaling pathways specify cell fates by activating transcriptional programs in response to extracellular signals. Extensive studies in the past 30 years have revealed that surprisingly fewpathways exist ...
-
Article
Synergy between bacterial infection and genetic predisposition in intestinal dysplasia
Apidianakis, Yiorgos; Pitsouli, Chrysoula; Perrimon, N.; Rahme, L. (2009)Accumulating evidence suggests that hyperproliferating intestinal stem cells (SCs) and progenitors drive cancer initiation, maintenance, and metastasis. In addition, chronic inflammation and infection have been increasingly ...